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Louis Aronne is a paid consultant and advisory board member for Eli Lilly and Company, the study sponsor and the manufacturer of orforglipron and tirzepatide.

GIP receptor involvement adds complexity to the allodynia mechanism

The better approach for most patients is a maintenance phase at a reduced dose, not abrupt discontinuation

Tracking your injections and timing Good tracking prevents timing mistakes

These interactions may either exacerbate toxicity or reduce therapeutic efficacy

Studies conducted in populations around the world indicate that there may be deficiencies in antioxidant and methylation metabolites (Liu et al